过氧亚硝酸盐
化学
氧化剂
荧光
纳米技术
活性氧
DNA损伤
生物物理学
DNA
组合化学
生物化学
酶
有机化学
超氧化物
物理
生物
材料科学
量子力学
作者
Shan Wang,Liyan Chen,Paramesh Jangili,Amit Sharma,Wei Li,Ji‐Ting Hou,Caiqin Qin,Juyoung Yoon,Jong Seung Kim
标识
DOI:10.1016/j.ccr.2018.06.013
摘要
Peroxynitrite (ONOO−) is one of the endogenous reactive oxygen species (ROS), which causes damage to a wide array of molecular components in the cells, including DNA and proteins, owing to its high oxidizing as well as nitrating properties. However, the precise pathogenic roles played by this substance in biological systems have not yet been elucidated completely owing to its short lifetime, high reactivity, low concentration and elusive nature in the in vivo applications. Thus, the development of more sensitive and selective techniques for detecting ONOO−, with high biocompatibilities, sensitivities, and site-specificities, is a significant goal. This review summarizes the recent advances that have been made in developing fluorescent sensors for ONOO− and their biological applications in diverse living systems.
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