自愈水凝胶
壳聚糖
椎间盘
化学
组织工程
生物医学工程
再生(生物学)
生物物理学
解剖
高分子化学
细胞生物学
生物化学
医学
生物
作者
Yasaman Alinejad,Atma Adoungotchodo,Michael P. Grant,Laura M. Epure,John Antoniou,Fackson Mwale,Sophie Lerouge
出处
期刊:Tissue Engineering Part A
[Mary Ann Liebert]
日期:2019-03-01
卷期号:25 (5-6): 303-313
被引量:46
标识
DOI:10.1089/ten.tea.2018.0170
摘要
A thermosensitive chitosan-based hydrogel was developed, which mimics the mechanical properties of the human nucleus pulposus (NP) tissue and provides a suitable environment for seeded NP cells to live and produce glycosaminoglycans. This scaffold is injectable through 25G needle and rapidly gels in vivo at body temperature. It has the potential to restore mechanical properties and stimulate biological repair of the degenerated intervertebral disc (IVD). It could therefore be used for the minimally invasive treatment of degenerated IVD, which affects more than one person out of five in the world.
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