材料科学
生物相容性
聚乙烯醇
生物相容性材料
3d打印
纳米技术
铸造
磁性纳米粒子
自愈水凝胶
纳米颗粒
复合材料
生物医学工程
高分子化学
工程类
冶金
作者
Roger Sanchis‐Gual,Hao Ye,Towa Ueno,Fabian C. Landers,Lukas Hertle,Siyu Deng,Andrea Veciana,Yanming Xia,Carlos Franco,Hongsoo Choi,Josep Puigmartí‐Luis,Bradley J. Nelson,Xiang‐Zhong Chen,Salvador Pané
标识
DOI:10.1002/adfm.202212952
摘要
Abstract The past decade has seen an upsurge in the development of small‐scale magnetic robots for various biomedical applications. However, many of the reported designs comprise components with biocompatibility concerns. Strategies for fabricating biocompatible and degradable microrobots are required. In this study, polyvinyl alcohol (PVA)‐based magnetic hydrogel microrobots with different morphologies and tunable stability are developed by combining a 3D printed template‐assisted casting with a salting‐out process. 3D sacrificial micromolds are prepared via direct laser writing to shape PVA‐magnetic nanoparticle composite hydrogel microrobots with high architectural complexity. By adjusting the PVA composition and salting‐out parameters, the hydrogel dissolubility can be customized. Due to their high mobility, tunable stability, and high biocompatibility, these PVA‐based magnetic microrobots are suitable platforms for targeted drug and cell delivery.
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