曲安奈德
地塞米松
医学
硬膜外腔
炎症
粘附
麻醉
神经根
皮质类固醇
内科学
外科
化学
有机化学
作者
Wenyangming Sun,Qian Li,Meng He,Dashou Wang,Xiaohua Zou
标识
DOI:10.1166/jbn.2023.3583
摘要
This study aimed to investigate the effect and mechanism of triamcinolone acetonide on nerve root inflammation and epidural adhesion in rabbits. The experiment involved 30 male New Zealand white rabbits, which were divided into three groups: Model, Dexamethasone, and Triamcinolone. After establishing the rabbit model of nerve root inflammation and epidural adhesion, dexamethasone and triamcinolone acetonide were injected through the epidural catheter. The results showed that triamcinolone acetonide significantly reduced nerve root inflammation, epidural adhesion, and nerve root pain. It also decreased the mRNA expression levels of NF-KB, TLR9, IL-6, and TNF- α in spinal cord tissue and spinal nerve roots. Compared with the dexamethasone group, the triamcinolone group had a lower Rydell-Balaz score, indicating less epidural adhesion. The Paw Withdraw Threshold and Paw Withdraw Latency decreased significantly in the triamcinolone group compared to the model group, and there was no obvious nerve root inflammatory reaction in the triamcinolone group. Therefore, epidural triamcinolone acetonide injection may be an effective treatment to reduce nerve root inflammation, epidural adhesion, and nerve root pain by inhibiting the NF-KB/TLR9-mediated inflammatory response.
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