Dysregulation of epigenetic, biological and mitotic age in the context of biologic drug treatment and phototherapy in plaque psoriasis patients

Journal of the European Academy of Dermatology and VenereologyEarly View LETTER TO THE EDITOR Dysregulation of epigenetic, biological and mitotic age in the context of biologic drug treatment and phototherapy in plaque psoriasis patients Richie Jeremian, Corresponding Author Richie Jeremian [email protected] orcid.org/0000-0001-9258-6296 Faculty of Medicine and Health Sciences, McGill University, Montréal, Quebec, Canada McGill University Health Centre (MUHC) Center of Excellence for Atopic Dermatitis, Montréal, Quebec, Canada Correspondence Richie Jeremian, Faculty of Medicine and Health Sciences, McGill University, Research Institute of the McGill University Health Centre (RI-MUHC), 1001 Decarie Boulevard, Montréal, QC H4A 3J1, Canada. Email: [email protected]Search for more papers by this authorYuliya Lytvyn, Yuliya Lytvyn orcid.org/0000-0003-1805-9994 Division of Dermatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, CanadaSearch for more papers by this authorRayyan Fotovati, Rayyan Fotovati Faculty of Medicine and Health Sciences, McGill University, Montréal, Quebec, CanadaSearch for more papers by this authorKaiyang Li, Kaiyang Li orcid.org/0000-0001-8557-166X Faculty of Medicine and Health Sciences, McGill University, Montréal, Quebec, Canada McGill University Health Centre (MUHC) Center of Excellence for Atopic Dermatitis, Montréal, Quebec, CanadaSearch for more papers by this authorAlexandra Malinowski, Alexandra Malinowski Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, CanadaSearch for more papers by this authorMuskaan Sachdeva, Muskaan Sachdeva orcid.org/0000-0002-2252-5663 Division of Dermatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, CanadaSearch for more papers by this authorCarolyn Jack, Carolyn Jack Faculty of Medicine and Health Sciences, McGill University, Montréal, Quebec, Canada McGill University Health Centre (MUHC) Center of Excellence for Atopic Dermatitis, Montréal, Quebec, CanadaSearch for more papers by this authorMelinda Gooderham, Melinda Gooderham orcid.org/0000-0001-8926-0113 SKiN Centre for Dermatology, Peterborough, Ontario, CanadaSearch for more papers by this authorDavid O. Croitoru, David O. Croitoru Division of Dermatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, CanadaSearch for more papers by this authorJensen Yeung, Jensen Yeung Division of Dermatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, CanadaSearch for more papers by this authorVincent Piguet, Vincent Piguet Division of Dermatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada Division of Dermatology, Department of Medicine, Women's College Hospital, Toronto, Ontario, CanadaSearch for more papers by this author Richie Jeremian, Corresponding Author Richie Jeremian [email protected] orcid.org/0000-0001-9258-6296 Faculty of Medicine and Health Sciences, McGill University, Montréal, Quebec, Canada McGill University Health Centre (MUHC) Center of Excellence for Atopic Dermatitis, Montréal, Quebec, Canada Correspondence Richie Jeremian, Faculty of Medicine and Health Sciences, McGill University, Research Institute of the McGill University Health Centre (RI-MUHC), 1001 Decarie Boulevard, Montréal, QC H4A 3J1, Canada. Email: [email protected]Search for more papers by this authorYuliya Lytvyn, Yuliya Lytvyn orcid.org/0000-0003-1805-9994 Division of Dermatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, CanadaSearch for more papers by this authorRayyan Fotovati, Rayyan Fotovati Faculty of Medicine and Health Sciences, McGill University, Montréal, Quebec, CanadaSearch for more papers by this authorKaiyang Li, Kaiyang Li orcid.org/0000-0001-8557-166X Faculty of Medicine and Health Sciences, McGill University, Montréal, Quebec, Canada McGill University Health Centre (MUHC) Center of Excellence for Atopic Dermatitis, Montréal, Quebec, CanadaSearch for more papers by this authorAlexandra Malinowski, Alexandra Malinowski Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, CanadaSearch for more papers by this authorMuskaan Sachdeva, Muskaan Sachdeva orcid.org/0000-0002-2252-5663 Division of Dermatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, CanadaSearch for more papers by this authorCarolyn Jack, Carolyn Jack Faculty of Medicine and Health Sciences, McGill University, Montréal, Quebec, Canada McGill University Health Centre (MUHC) Center of Excellence for Atopic Dermatitis, Montréal, Quebec, CanadaSearch for more papers by this authorMelinda Gooderham, Melinda Gooderham orcid.org/0000-0001-8926-0113 SKiN Centre for Dermatology, Peterborough, Ontario, CanadaSearch for more papers by this authorDavid O. Croitoru, David O. Croitoru Division of Dermatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, CanadaSearch for more papers by this authorJensen Yeung, Jensen Yeung Division of Dermatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, CanadaSearch for more papers by this authorVincent Piguet, Vincent Piguet Division of Dermatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada Division of Dermatology, Department of Medicine, Women's College Hospital, Toronto, Ontario, CanadaSearch for more papers by this author First published: 15 April 2024 https://doi.org/10.1111/jdv.19978Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1Armstrong AW, Koning JW, Rowse S, Tan H, Mamolo C, Kaur M. Initiation, switching, and cessation of psoriasis treatments among patients with moderate to severe psoriasis in the United States. Clin Drug Investig. 2017; 37(5): 493–501. 10.1007/s40261-017-0508-1 PubMedWeb of Science®Google Scholar 2Levine ME, Lu AT, Quach A, Chen BH, Assimes TL, Bandinelli S, et al. An epigenetic biomarker of aging for lifespan and healthspan. Aging (Albany NY). 2018; 10(4): 573–591. 10.18632/aging.101414 PubMedGoogle Scholar 3Higgins-Chen AT, Thrush KL, Wang Y, Minteer CJ, Kuo P-L, Wang M, et al. A computational solution for bolstering reliability of epigenetic clocks: implications for clinical trials and longitudinal tracking. Nat Aging. 2022; 2(7): 644–661. 10.1038/s43587-022-00248-2 PubMedGoogle Scholar 4Teschendorff AE. A comparison of epigenetic mitotic-like clocks for cancer risk prediction. Genome Med. 2020; 12(1): 56. 10.1186/s13073-020-00752-3 CASPubMedWeb of Science®Google Scholar 5Lu AT, Seeboth A, Tsai PC, Sun D, Quach A, Reiner AP, et al. DNA methylation-based estimator of telomere length. Aging (Albany NY). 2019; 11(16): 5895–5923. 10.18632/aging.102173 CASPubMedGoogle Scholar 6Salas LA, Zhang Z, Koestler DC, Butler RA, Hansen HM, Molinaro AM, et al. Enhanced cell deconvolution of peripheral blood using DNA methylation for high-resolution immune profiling. Nat Commun. 2022; 13(1): 761. 10.1038/s41467-021-27864-7 CASPubMedWeb of Science®Google Scholar 7Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013; 14(10): 3156. 10.1186/gb-2013-14-10-r115 Web of Science®Google Scholar 8Horvath S, Raj K. DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nat Rev Genet. 2018; 19(6): 371–384. 10.1038/s41576-018-0004-3 CASPubMedWeb of Science®Google Scholar 9Kabacik S, Lowe D, Fransen L, Leonard M, Ang S-L, Whiteman C, et al. The relationship between epigenetic age and the hallmarks of aging in human cells. Nat Aging. 2022; 2(6): 484–493. 10.1038/s43587-022-00220-0 PubMedGoogle Scholar 10Lu AT, Quach A, Wilson JG, Reiner AP, Aviv A, Raj K, et al. DNA methylation GrimAge strongly predicts lifespan and healthspan. Aging (Albany NY). 2019; 11(2): 303–327. 10.18632/aging.101684 CASPubMedGoogle Scholar Early ViewOnline Version of Record before inclusion in an issue ReferencesRelatedInformation