封堵器
紧密连接
粘合连接
血睾丸屏障
精子发生
生物
内科学
势垒函数
细胞结
细胞生物学
男科
内分泌学
化学
支持细胞
生物化学
医学
钙粘蛋白
细胞
作者
Xiaowei Li,Li Sheng,Yu Yang,Milton Talukder,Xiaoshu Xu,Chenxi Li,Cong Zhang,Xue‐Nan Li,Jin‐Long Li
标识
DOI:10.1016/j.jhazmat.2024.134126
摘要
Cadmium (Cd) is a well-known testis toxicant. The blood-testis barrier (BTB) is a crucial component of the testis. Cd can disrupt the integrity of the BTB and reproductive function. However, the mechanism of Cd-induced disruption of BTB and testicular damage has not been fully elucidated. Here, our study investigates the effects of Cd on BTB integrity and testicular dysfunction. 80 (aged 1 day) Hy-Line white variety chickens were randomly designed into 4 groups and treated for 90 days, as follows: control group (essential diet), 35 Cd, 70 Cd and 140 Cd groups (35, 70 and 140 mg kg-1 Cd). The results found that Cd exposure diminished volume of the testes and induced histopathological lesions in the testes. Exposure to Cd induced an inflammatory response, disrupted the structure and function of the FAK/occludin/ZO-1 protein complex and disrupted the tight junction and adherens junction in the BTB. In addition, Cd exposure reduced the expression of steroid-related proteins and inhibited testosterone synthesis. Taken together, these data elucidate that Cd disrupts the integrity of the BTB and further inhibits spermatogenesis by dissociating the FAK/occludin/ZO-1 complex, which provides a basis for further investigation into the mechanisms of Cd-induced impairment of male reproductive function and pharmacological protection.
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