前药
紫杉醇
二茂铁
组合化学
体内
谷胱甘肽
化学
材料科学
化疗
有机化学
生物化学
酶
生物
电化学
电极
遗传学
物理化学
生物技术
作者
Shaojin Lu,Dengyuan Hao,Qian Meng,Baohua Zhang,Xiujuan Xiang,Qing Pei,Zhigang Xie
标识
DOI:10.1021/acsami.4c11418
摘要
Herein, we developed a paclitaxel prodrug (PSFc) through the conjugation of paclitaxel (PTX) and ferrocene via a redox-responsive disulfide bond. PSFc displays acid-enhanced catalytic activity of Fenton reaction and is capable of forming stable nanoparticles (PSFc NPs) through the assembly with distearoyl phosphoethanolamine-PEG2000. After being endocytosed, PSFc NPs could release PTX to promote cell apoptosis in response to overexpressed redox-active species of tumor cells. Meanwhile, the ferrocene-mediated Fenton reaction promotes intracellular accumulation of hydroxyl radicals and depletion of glutathione, thus leading to ferroptosis. Compared with the clinically used Taxol, PSFc NPs exhibited more potent in vivo antitumor outcomes through the combined effect of chemotherapy and ferroptosis. This study may offer insight into a facile design of a prodrug integrating different tumor treatment methods for combating malignant tumors.
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