光动力疗法
活性氧
光子上转换
光敏剂
肿瘤微环境
氧气
癌细胞
材料科学
癌症研究
化学
单线态氧
生物物理学
纳米技术
光化学
癌症
兴奋剂
肿瘤细胞
光电子学
生物化学
医学
生物
有机化学
内科学
作者
Huiyuan Chu,Yameng Li,Chaozhan Wang,Jiwei Shen,Yinmao Wei
出处
期刊:Dalton Transactions
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:51 (42): 16336-16343
被引量:2
摘要
Excessive production of intracellular reactive oxygen species (ROS) can induce apoptosis of cancer cells; however, it is often limited by severe triggering conditions and hypoxic microenvironments of solid tumors. To address these issues, herein, we have designed a MOF-coated upconversion nanoconstruct (UCTSCF, referring to UC@Ce6/TFS@mSiO2@MIL-100(Cu/Fe)) for synergetic photochemodynamic therapy (PCT)/oxygen-elevated photodynamic therapy (PDT). The MOF (MIL-100(Fe)) coating with Cu-doping was designed to catalyze H2O2 overexpression in cancer cells to generate the most cytotoxic ˙OH via chemodynamic therapy (CDT). It is noted that UC, representing 808 nm driven upconversion nanoparticles with high tissue penetration depth/low over-heating effects, was designed to provide intense blue light which can relieve the severe triggering conditions of CDT via PCT. Furthermore, the functional layer of the photosensitizer chlorin e6 (Ce6) and O2-carrying triethoxy(1H,1H,2H,2H-nonafluorohexyl)silane (TFS) co-doped mesoporous silicon (Ce6/TFS@mSiO2) can cause oxygen-elevated 1O2 production upon 671 nm light irradiation. In such a simple ROS generation nanoplatform, we heighten the antitumor effect via oxygen-elevated synergetic tumor PCT/PDT.
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