Ring‐Opening Polymerization with Synergistic Co‐monomers: Access to a Boronate‐Functionalized Polymeric Monolith for the Specific Capture of cis‐Diol‐Containing Biomolecules under Neutral Conditions

Angewandte Chemie International EditionVolume 48, Issue 36 p. 6704-6707 Communication Ring-Opening Polymerization with Synergistic Co-monomers: Access to a Boronate-Functionalized Polymeric Monolith for the Specific Capture of cis-Diol-Containing Biomolecules under Neutral Conditions† Lianbing Ren, Lianbing Ren Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 22 Hankou Road, Nanjing 210093 (China), Fax: (+86) 25-8368-5639Search for more papers by this authorZhen Liu Dr., Zhen Liu Dr. zhenliu@nju.edu.cn Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 22 Hankou Road, Nanjing 210093 (China), Fax: (+86) 25-8368-5639Search for more papers by this authorYunchun Liu, Yunchun Liu Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 22 Hankou Road, Nanjing 210093 (China), Fax: (+86) 25-8368-5639Search for more papers by this authorPeng Dou, Peng Dou Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 22 Hankou Road, Nanjing 210093 (China), Fax: (+86) 25-8368-5639Search for more papers by this authorHong-Yuan Chen Prof., Hong-Yuan Chen Prof. Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 22 Hankou Road, Nanjing 210093 (China), Fax: (+86) 25-8368-5639Search for more papers by this author Lianbing Ren, Lianbing Ren Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 22 Hankou Road, Nanjing 210093 (China), Fax: (+86) 25-8368-5639Search for more papers by this authorZhen Liu Dr., Zhen Liu Dr. zhenliu@nju.edu.cn Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 22 Hankou Road, Nanjing 210093 (China), Fax: (+86) 25-8368-5639Search for more papers by this authorYunchun Liu, Yunchun Liu Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 22 Hankou Road, Nanjing 210093 (China), Fax: (+86) 25-8368-5639Search for more papers by this authorPeng Dou, Peng Dou Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 22 Hankou Road, Nanjing 210093 (China), Fax: (+86) 25-8368-5639Search for more papers by this authorHong-Yuan Chen Prof., Hong-Yuan Chen Prof. Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 22 Hankou Road, Nanjing 210093 (China), Fax: (+86) 25-8368-5639Search for more papers by this author First published: 19 August 2009 https://doi.org/10.1002/anie.200902469Citations: 184 † We gratefully acknowledge the financial support of a General Grant (No. 20675038) from the National Natural Science Foundation of China, a Key Grant of 973 Program (No. 2007CB914102), an International Science & Technology Cooperation Grant (2008DFA01910) from the Ministry of Science and Technology of China, and a General Grant (No. KB2008258) to Z.L. from the Natural Science Foundation of Jiangsu Province. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Molecular teamwork: Synergistic co-monomers contained in a boronate-functionalized polymeric monolith function as a single Wulff-type boronic acid ligand to enable the specific capture of cis-diol-containing biomolecules under neutral conditions (see scheme). When the medium is made more acidic, the amine group is protonated, and B–N coordination is broken, which results in the release of the cis diol from the monolith. Citing Literature Volume48, Issue36August 24, 2009Pages 6704-6707 RelatedInformation