Association between circulating vitamin E and ten common cancers: evidence from large-scale Mendelian randomization analysis and a longitudinal cohort study

医学 孟德尔随机化 肿瘤科 内科学 全基因组关联研究 癌症 乳腺癌 前列腺癌 卵巢癌 优势比 病例对照研究 癌症预防 单核苷酸多态性 基因型 遗传学 基因 生物 遗传变异
作者
Junyi Xin,Xia Jiang,Shuai Ben,Qian Yuan,Su Li,Zhengdong Zhang,David C. Christiani,Mulong Du,Meilin Wang
出处
期刊:BMC Medicine [BioMed Central]
卷期号:20 (1) 被引量:19
标识
DOI:10.1186/s12916-022-02366-5
摘要

Abstract Background The association between vitamin E and cancer risk has been widely investigated by observational studies, but the findings remain inconclusive. Here, we aimed to evaluate the causal effect of circulating vitamin E on the risk of ten common cancers, including bladder, breast, colorectal, esophagus, lung, oral and pharynx, ovarian, pancreatic, prostate, and kidney cancer. Methods A Mendelian randomization (MR) analytic framework was applied to data from a cancer-specific genome-wide association study (GWAS) comprising a total of 297,699 cancer cases and 304,736 controls of European ancestry. Three genetic instrumental variables associated with circulating vitamin E were selected. Summary statistic-based methods of inverse variance weighting (IVW) and likelihood-based approach, as well as the individual genotyping-based method of genetic risk score (GRS) were used. Multivariable IVW analysis was further performed to control for potential confounding effects. Furthermore, the UK Biobank cohort was used as external validation, supporting 355,543 European participants (incident cases ranged from 437 for ovarian cancer to 4882 for prostate cancer) for GRS-based estimation of circulating vitamin E, accompanied by a one-sample MR analysis of dietary vitamin E intake underlying the time-to-event analytic framework. Results Specific to cancer GWAS, we found that circulating vitamin E was significantly associated with increased bladder cancer risk (odds ratios [OR] IVW = 6.23, P IVW = 3.05×10 -3 ) but decreased breast cancer risk (OR IVW = 0.68, P IVW = 8.19×10 -3 ); however, the significance of breast cancer was dampened ( P multivariable IVW > 0.05) in the subsequent multivariable MR analysis. In the validation stage of the UK Biobank cohort, we did not replicate convincing causal effects of genetically predicted circulating vitamin E concentrations and dietary vitamin E intake on the risk of ten cancers. Conclusions This large-scale population study upon data from cancer-specific GWAS and a longitudinal biobank cohort indicates plausible non-causal associations between circulating vitamin E and ten common cancers in the European populations. Further studies regarding ancestral diversity are warranted to validate such causal associations.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
kkk完成签到,获得积分10
刚刚
摆烂fish完成签到,获得积分10
1秒前
可爱的函函应助lumcy采纳,获得10
2秒前
www发布了新的文献求助10
2秒前
zyj完成签到,获得积分10
2秒前
tong77发布了新的文献求助10
2秒前
乐观小之应助科研通管家采纳,获得10
3秒前
乐观小之应助科研通管家采纳,获得10
3秒前
8R60d8应助科研通管家采纳,获得10
3秒前
Orange应助科研通管家采纳,获得10
3秒前
充电宝应助科研通管家采纳,获得10
3秒前
英俊的铭应助科研通管家采纳,获得10
3秒前
跳跃幻丝应助科研通管家采纳,获得10
3秒前
酷波er应助科研通管家采纳,获得10
4秒前
CipherSage应助科研通管家采纳,获得10
4秒前
4秒前
8R60d8应助科研通管家采纳,获得10
4秒前
我是老大应助科研通管家采纳,获得10
4秒前
自然发布了新的文献求助10
4秒前
传奇3应助科研通管家采纳,获得10
4秒前
4秒前
4秒前
4秒前
5秒前
沧笙踏歌发布了新的文献求助10
6秒前
Docgrace发布了新的文献求助10
6秒前
7秒前
司空豁发布了新的文献求助10
8秒前
9秒前
9秒前
Akim应助www采纳,获得10
10秒前
11秒前
12秒前
Sylvia完成签到,获得积分10
13秒前
13秒前
14秒前
思源应助888采纳,获得10
14秒前
小野猫发布了新的文献求助10
15秒前
17秒前
高分求助中
The Mother of All Tableaux Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 2400
Ophthalmic Equipment Market by Devices(surgical: vitreorentinal,IOLs,OVDs,contact lens,RGP lens,backflush,diagnostic&monitoring:OCT,actorefractor,keratometer,tonometer,ophthalmoscpe,OVD), End User,Buying Criteria-Global Forecast to2029 2000
Optimal Transport: A Comprehensive Introduction to Modeling, Analysis, Simulation, Applications 800
Official Methods of Analysis of AOAC INTERNATIONAL 600
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 588
T/CIET 1202-2025 可吸收再生氧化纤维素止血材料 500
Interpretation of Mass Spectra, Fourth Edition 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3956458
求助须知:如何正确求助?哪些是违规求助? 3502568
关于积分的说明 11108738
捐赠科研通 3233292
什么是DOI,文献DOI怎么找? 1787239
邀请新用户注册赠送积分活动 870565
科研通“疑难数据库(出版商)”最低求助积分说明 802122