Paradoxical reactions and biologic agents: a French cohort study of 9303 patients*

医学 内科学 优势比 入射(几何) 队列 风湿病 银屑病 炎症性肠病 置信区间 溃疡性结肠炎 队列研究 疾病 胃肠病学 免疫学 光学 物理
作者
P. Bataille,Richard Layese,Pascal Claudepierre,Nicolas Paris,Julien Dubiel,Aurélien Amiot,Emilie Sbidian
出处
期刊:British Journal of Dermatology [Oxford University Press]
卷期号:187 (5): 676-683 被引量:3
标识
DOI:10.1111/bjd.21716
摘要

Background Paradoxical reactions (PRs) are defined as the occurrence during biologic therapy of a pathological condition that usually responds to these drugs. Objectives To estimate the incidence of PRs and identify risk factors. Methods Multicentre study of the database for the Greater Paris University Hospitals, including biologic-naive patients receiving anti-tumour necrosis factor-α, anti-interleukin-12/23, anti-interleukin-17 or anti-α4β7-integrin agents for psoriasis, inflammatory rheumatism or inflammatory bowel disease (IBD). We used natural language processing algorithms to extract data. A cohort and a case–control study nested in the cohort with controls selected by incidence density sampling was used to identify risk factors. Results Most of the 9303 included patients (median age 43·0, 53·8% women) presented an IBD (3773, 40·6%) or a chronic inflammatory rheumatic disease (3708, 39·9%), and 8489 (91·3%) received anti-TNF-α agents. A total of 297 (3·2%) had a PR. The global incidence rate was 7·6 per 1000 person-years [95% confidence interval (CI) 6·8–8·5]. The likelihood of PR was associated with IBD [adjusted odds ratio (aOR) 1·9, 95% CI 1·1–3·2, P = 0·021] and a combination of at least two inflammatory diseases (aOR 6·1, 95% CI 3·6–10·6, P < 0·001) and was reduced with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) and corticosteroids (aOR 0·6, 95% CI 0·4–0·8, P = 0·002; and OR 0·4, 95% CI 0·2–0·6, P = 0·002, respectively). Conclusions The likelihood of PRs was associated with IBD or a combination of a least two inflammatory diseases. More studies are needed to assess the benefit of systematically adding csDMARDs for such high-risk patients. What is already known about this topic? Most published studies about paradoxical reactions concern paradoxical psoriasis in patients receiving anti-tumour necrosis factor-α agents. Few data are available for other paradoxical reactions and the most recent biologics. What does this study add? Risk of paradoxical reactions was increased with inflammatory bowel disease and a combination of at least two inflammatory diseases. Risk of paradoxical reactions was reduced with conventional synthetic disease-modifying antirheumatic drugs or corticosteroid therapy, which could be added for high-risk patients.
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