A Rare Case of Adrenal Cysts Associated With Bilateral Incidentalomas and Diffuse Hyperplasia of the Zona Glomerulosa

肾小球带 醛固酮 医学 增生 肾上腺皮质癌 肾上腺 病理 内科学 血管紧张素II 血压
作者
Naru Babaya,Yuki Okuda,Shinsuke Noso,Yoshihisa Hiromine,Yasunori Taketomo,Fumimaru Niwano,Kazuki Ueda,Yumiko Oishi Tanaka,Yuto Yamazaki,Hironobu Sasano,Yumiko Kawabata,Yasuhiro Ohno,Hiroshi Ikegami
出处
期刊:Journal of the Endocrine Society [The Endocrine Society]
被引量:2
标识
DOI:10.1210/jendso/bvaa184
摘要

Abstract Characterization of adrenocortical disorders is challenging because of varying origins, laterality, the presence or absence of hormone production, and unclarity about the benign or malignant nature of the lesion. Histopathological examination in conjunction with immunohistochemistry is generally considered mandatory in this characterization. We report a rare case of bilateral adrenocortical adenomas associated with unilateral adrenal endothelial cysts in a 65-year-old woman whose condition was not diagnosed before surgery. Detailed histological examination of the resected adrenal glands revealed hyperplasia in the zona glomerulosa. Despite hyperplasia, the patient had normal serum aldosterone levels and renin activity without clinical evidence of hypertension. The patient was treated with a sodium-glucose cotransporter protein 2 (SGLT2) inhibitor. This may have stimulated the renin-angiotensin-aldosterone system. To the best of our knowledge, this is the first case in which both relatively large bilateral adrenocortical adenomas and unilateral adrenal endothelial cysts were detected. This case also highlights the complexity and difficulty of preoperative diagnosis. Furthermore, this case reports the first detailed histopathological examination of adrenal lesions with SGLT2 treatment and the possibility of SGLT2 inhibitor treatment resulting in histological hyperplasia in the zona glomerulosa; however, it is difficult to prove a causative relationship between SGLT2 inhibitors and hyperplasia of the zona glomerulosa based on the data of this case. It can be confirmed only under limited conditions; therefore, further studies on adrenal gland histology employing SGLT2 inhibition are warranted.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
隐形曼青应助pojian采纳,获得10
1秒前
1秒前
精明尔曼完成签到,获得积分10
3秒前
彭于晏应助孤独的金针菇采纳,获得10
4秒前
Owen应助ed采纳,获得10
4秒前
小二郎应助Lucifer2012采纳,获得10
5秒前
5秒前
5秒前
谦让泽洋发布了新的文献求助10
6秒前
9秒前
9秒前
顽固的肉发布了新的文献求助10
11秒前
12秒前
嗯嗯发布了新的文献求助10
13秒前
xukeyi完成签到,获得积分10
13秒前
zeal发布了新的文献求助10
14秒前
李爱国应助huangJP采纳,获得10
14秒前
15秒前
17秒前
脑洞疼应助timo采纳,获得10
17秒前
上官若男应助雨落采纳,获得10
18秒前
红枫没有微雨怜完成签到 ,获得积分10
18秒前
Celestine完成签到,获得积分10
19秒前
19秒前
susu完成签到,获得积分10
21秒前
21秒前
SCI发布了新的文献求助10
21秒前
研友_VZG7GZ应助1111采纳,获得10
22秒前
22秒前
劲秉应助hub采纳,获得10
23秒前
求文得文发布了新的文献求助10
23秒前
努努完成签到 ,获得积分10
23秒前
24秒前
25秒前
jessie完成签到,获得积分10
26秒前
vippp发布了新的文献求助10
27秒前
28秒前
鸭梨发布了新的文献求助10
30秒前
可口可乐了完成签到,获得积分10
30秒前
良药苦口发布了新的文献求助10
32秒前
高分求助中
Production Logging: Theoretical and Interpretive Elements 2500
Healthcare Finance: Modern Financial Analysis for Accelerating Biomedical Innovation 2000
Agaricales of New Zealand 1: Pluteaceae - Entolomataceae 1040
Les Mantodea de Guyane Insecta, Polyneoptera 1000
지식생태학: 생태학, 죽은 지식을 깨우다 600
Crystal structures of UP2, UAs2, UAsS, and UAsSe in the pressure range up to 60 GPa 570
Mantodea of the World: Species Catalog Andrew M 500
热门求助领域 (近24小时)
化学 医学 材料科学 生物 工程类 有机化学 生物化学 纳米技术 内科学 物理 化学工程 计算机科学 复合材料 基因 遗传学 物理化学 催化作用 细胞生物学 免疫学 电极
热门帖子
关注 科研通微信公众号,转发送积分 3465739
求助须知:如何正确求助?哪些是违规求助? 3058804
关于积分的说明 9063252
捐赠科研通 2749200
什么是DOI,文献DOI怎么找? 1508377
科研通“疑难数据库(出版商)”最低求助积分说明 696893
邀请新用户注册赠送积分活动 696585