Vitamin B6 Biosynthesis: Charting the Mechanistic Landscape

Enzyme of the rings: Vitamin B6 biosynthesis through the DXP-independent route is catalyzed by PLP synthase. The enzyme utilizes ribose 5-phosphate, glyceraldehyde 3-phosphate and ammonia to synthesize the cofactor form of the vitamin, pyridoxal 5′-phosphate (PLP). This review provides the emerging mechanistic details of this remarkable Pdx1:Pdx2 glutamine amidotransferase complex.