衣原体
免疫系统
沙眼衣原体
免疫学
生物
抗原
免疫
沙眼衣原体感染
获得性免疫系统
T细胞
病毒学
作者
Jennifer D. Helble,Michael N. Starnbach
标识
DOI:10.1093/femspd/ftab014
摘要
Chlamydia trachomatis is the most commonly reported sexually transmitted infection in the United States. The high prevalence of infection and lack of a vaccine indicate a critical knowledge gap surrounding the host's response to infection and how to effectively generate protective immunity. The immune response to C. trachomatis is complex, with cells of the adaptive immune system playing a crucial role in bacterial clearance. Here, we discuss the CD4+ and CD8+ T cell response to Chlamydia, the importance of antigen specificity and the role of memory T cells during the recall response. Ultimately, a deeper understanding of protective immune responses is necessary to develop a vaccine that prevents the inflammatory diseases associated with Chlamydia infection.
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