An efficient, catalyst and solvent free Staudinger phosphite reaction for the synthesis of phosphoramidates under mild conditions

An efficient, catalyst-free and solvent-free protocol has been developed for the synthesis of phosphoramidates. This method can be used to synthesize phosphoramidates from diverse starting materials including aryl/benzyl and alkyl azides at room temperature. The synthesis is simple, selective and high yielding with notably a very short reaction time. The process involves mild reaction conditions which allow for sensitive functionalities and protecting groups to be used in the developed protocol that is of great advantage and could provide valuable reference for the construction of more complex heterocyclic linked phosphoramidate systems with biological and medicinal importance.