生物
RNA剪接
环状RNA
翻译(生物学)
核糖核酸
计算生物学
细胞生物学
选择性拼接
RNA结合蛋白
外显子
非编码RNA
遗传学
信使核糖核酸
基因
作者
Chu‐Xiao Liu,Ling‐Ling Chen
出处
期刊:Cell
[Elsevier]
日期:2022-05-17
卷期号:185 (12): 2016-2034
被引量:465
标识
DOI:10.1016/j.cell.2022.04.021
摘要
Summary
Most circular RNAs are produced from the back-splicing of exons of precursor mRNAs. Recent technological advances have in part overcome problems with their circular conformation and sequence overlap with linear cognate mRNAs, allowing a better understanding of their cellular roles. Depending on their localization and specific interactions with DNA, RNA, and proteins, circular RNAs can modulate transcription and splicing, regulate stability and translation of cytoplasmic mRNAs, interfere with signaling pathways, and serve as templates for translation in different biological and pathophysiological contexts. Emerging applications of RNA circles to interfere with cellular processes, modulate immune responses, and direct translation into proteins shed new light on biomedical research. In this review, we discuss approaches used in circular RNA studies and the current understanding of their regulatory roles and potential applications.
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