Piperine inhibits AML-12 hepatocyte EMT and LX-2 HSC activation and alleviates mouse liver fibrosis provoked by CCl4: roles in the activation of the Nrf2 cascade and subsequent suppression of the TGF-β1/Smad axis

Piperine inhibits hepatocyte EMT and HSC activation and ameliorates mouse liver fibrosis provoked by CCl 4 via activating Nrf2 and subsequently suppressing TGF-β1/Smad signaling.