Gold nanoclusters: An ultrasmall platform for multifaceted applications

Gold nanoclusters (Au NCs) with a core size below 2 nm form an exciting class of functional nano-materials with characteristic physical and chemical properties. The properties of Au NCs are more prominent and extremely different from their bulk counterparts. The synthesis of Au NCs is generally assisted by template or ligand, which impart excellent cluster stability and high quantum yield. The tunable and sensitive physicochemical properties of Au NCs open horizons for their advanced applications in various interdisciplinary fields. In this review, we briefly summarize the solution phase synthesis and origin of the characteristic properties of Au NCs. A vast review of recent research work introducing biosensors based on Au NCs has been presented along with their specifications and detection limits. This review also highlights recent progress in the use of Au NCs as bio-imaging probe, enzyme mimic, temperature sensing probe and catalysts. A speculation on present challenges and certain future prospects have also been provided to enlighten the path for advancement of multifaceted applications of Au NCs.