免疫系统
生物
免疫学
获得性免疫系统
CCL18型
免疫
先天性淋巴细胞
先天免疫系统
细胞因子
神经科学
细胞生物学
作者
Sharon S. Evans,Elizabeth A. Repasky,Daniel T. Fisher
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2015-05-15
卷期号:15 (6): 335-349
被引量:948
摘要
This Review considers the impact of host temperature on the immune system. In particular, the authors focus on how the thermal element of the fever response can shape both innate and adaptive immune responses. Fever is a cardinal response to infection that has been conserved in warm-blooded and cold-blooded vertebrates for more than 600 million years of evolution. The fever response is executed by integrated physiological and neuronal circuitry and confers a survival benefit during infection. In this Review, we discuss our current understanding of how the inflammatory cues delivered by the thermal element of fever stimulate innate and adaptive immune responses. We further highlight the unexpected multiplicity of roles of the pyrogenic cytokine interleukin-6 (IL-6), both during fever induction and during the mobilization of lymphocytes to the lymphoid organs that are the staging ground for immune defence. We also discuss the emerging evidence suggesting that the adrenergic signalling pathways associated with thermogenesis shape immune cell function.
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