Naphthyridines with Antiviral Activity - A Review

Background: Naphthyridine scaffold is an important pharmacophore in compounds which have shown various biological activities like antiviral, antimicrobial, anticancer, antiinflammatory and analgesic. This scaffold is also reported to exhibit activity against HIV, HCMV, HSV, HPV and HCV. Antiviral activity displayed by many naphthyridine analogs is in nM range. Only few review articles are available in literature which describe about various biological activities of naphthyridines, but there is no comprehensive compilation particularly for antiviral activities. Keywords: 1, 6-naphthyridine, 1, 8-naphthyridine, antiviral, anti-HCMV, anti-HSV, anti-HIV, anti-HPV and anti-HCV.