谷氨酸的
神经科学
顺行追踪
外侧下丘脑
导水管周围灰质
下丘脑
兴奋性突触后电位
谷氨酸受体
化学
生物
中枢神经系统
中脑
受体
抑制性突触后电位
生物化学
作者
Li Chen,Ping Cai,Renfei Wang,Yiping Lu,Huiyun Chen,Yu-Rou Guo,Shengnan Huang,Lihuan Hu,Jian Chen,Ze-Hong Zheng,Peng He,Bingfeng Zhang,Jiyuan Liu,Wenxiang Wang,Huangyuan Li,Chang‐Xi Yu
标识
DOI:10.1016/j.neuropharm.2020.108239
摘要
The glutamatergic lateral hypothalamus (LH) has been implicated in a variety of behaviors, such as evasion and feeding, while its role in defensive behaviors and relevant neurocircuits remains unclear. Here, we demonstrated that the glutamatergic LH is a critical structure regulating defensive behaviors. Trimethylthiazole (TMT), the odor of mice predator, significantly increased c-Fos expression in the LH. Using fiber photometry technology, we found that TMT exposure increased the activity of LH glutamatergic neurons. Selective activation of LH glutamatergic neurons with optogenetics and chemogenetics promoted a series of defense-related behaviors, including fleeing, avoidance, and hiding, while selective inhibition of LH glutamatergic neurons suppressed the avoidance provoked by TMT. Activation of both the glutamatergic LH terminals in the hypothalamic paraventricular nucleus (PVN) and the glutamatergic projection from the basolateral amygdala (BLA) to the LH elicited defensive behaviors. Finally, by combining the viral-mediated retrograde tracing with anterograde activation, we found that PVN-projecting glutamatergic neurons in the LH were activated by BLA glutamatergic inputs. Taken together, our results illustrate that the glutamatergic LH is a pivotal relay of defensive behaviors and possibly promotes these behaviors through the BLA→LH→PVN pathway.
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