肿瘤微环境
微泡
癌细胞
癌相关成纤维细胞
间质细胞
癌症研究
转移
癌症
生物
重编程
外体
肿瘤进展
细胞生物学
小RNA
细胞
肿瘤细胞
生物化学
遗传学
基因
作者
Khandan Ilkhani,Milad Bastami,Soheila Delgir,Asma Safi,Shahrzad Talebian,Mohammad Reza Alivand
出处
期刊:Anti-cancer Agents in Medicinal Chemistry
[Bentham Science]
日期:2020-12-31
卷期号:21 (2): 254-266
被引量:23
标识
DOI:10.2174/1871520620666200910123428
摘要
: Metabolic reprogramming is a significant property of various cancer cells, which most commonly arises from the Tumor Microenvironment (TME). The events of metabolic pathways include the Warburg effect, shifting in Krebs cycle metabolites, and the rate of oxidative phosphorylation, potentially providing energy and structural requirements for the development and invasiveness of cancer cells. TME and tumor metabolism shifting have a close relationship through bidirectional signaling pathways between stromal and tumor cells. Cancer- Associated Fibroblasts (CAFs), as the most dominant cells of TME, play a crucial role in the aberrant metabolism of cancer. Furthermore, the stated relationship can affect survival, progression, and metastasis in cancer development. Recently, exosomes are considered one of the most prominent factors in cellular communications considering effective content and bidirectional mediatory effect between tumor and stromal cells. In this regard, CAF-Derived Exosomes (CDE) exhibit an efficient obligation to induce metabolic reprogramming for promoting growth and metastasis of cancer cells. The understanding of cancer metabolism, including factors related to TME, could lead to the discovery of a potential biomarker for diagnostic and therapeutic approaches in cancer management. This review focuses on the association between metabolic reprogramming and engaged microenvironmental, factors such as CAFs, and the associated derived exosomes.
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