Research progress in relationship between angiogenin-Tie2 signaling pathways and sepsis

Angiopoietin(Ang)is a secreted endothelial cell specific growth factor.Ang 2 levels in the body increase in bloodstream during infection.Studies have demonstrated that Ang 2 is a potential therapeutic target in sepsis.This paper reviews the biological function of Ang 2-Tie2 and Ang 2 inhibitors for a potential role of sepsis treatment. Key words: Sepsis; Ang1; Ang2; Tie2; Inflammation