伊库利珠单抗
医学
阵发性夜间血红蛋白尿
怀孕
不利影响
产科
血红蛋白尿
儿科
内科学
贫血
补体系统
免疫学
抗体
遗传学
生物
作者
Richard J. Kelly,Britta Höchsmann,Jeff Szer,Austin Kulasekararaj,Sophie de Guibert,Alexander Röth,Ilene C. Weitz,Elina Armstrong,Antonio M. Risitano,Christopher J. Patriquin,Louis Terriou,Petra Muus,Anita Hill,Michelle Turner,Hubert Schrezenmeier,Régis Peffault de Latour
标识
DOI：10.1056/nejmoa1502950
摘要
Eculizumab, a humanized monoclonal antibody against complement protein C5 that inhibits terminal complement activation, has been shown to prevent complications of paroxysmal nocturnal hemoglobinuria (PNH) and improve quality of life and overall survival, but data on the use of eculizumab in women during pregnancy are scarce.
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