医学
有效扩散系数
峰度
直方图
核医学
多发性骨髓瘤
磁共振弥散成像
偏斜
放射科
磁共振成像
内科学
统计
人工智能
数学
计算机科学
图像(数学)
作者
Qingyan Qi,Huazheng Dong,Xiaodong Ji,Kemin Zhang,Dehui Zou,Mu Hao,Shuhui Deng,Weiwei Sui,Zhiyi Song,Zhuo Yu,Zhiwei Shen,Wenyang Huang,Shuang Xia
出处
期刊:Future Oncology
[Future Medicine]
日期:2023-06-01
卷期号:19 (17): 1175-1185
标识
DOI:10.2217/fon-2023-0205
摘要
Aim: To assess baseline histogram parameters from apparent diffusion coefficient (ADC) images in predicting early treatment response in newly diagnosed multiple myeloma (NDMM) patients. Methods: The histogram parameters of lesions in 68 NDMM patients were obtained with the Firevoxel software. The presence of deep response after two cycles of induction was recorded. Results: Some parameters were significantly different between the two groups, for example, ADC 75% in lumbar spine (p = 0.026). No significant difference in mean ADC for any anatomic site was found (all p > 0.05). The combination of ADC 75, ADC 90 and ADC 95% in lumbar spine; ADC skewness and ADC kurtosis in rib achieved a sensitivity of 100% in predicting deep response. Conclusion: Histogram analysis of ADC images can describe NDMM heterogeneity and accurately predict treatment response.
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