Single-cell sequencing revealed metabolic reprogramming and its transcription factor regulatory network in prostate cancer

转录因子 前列腺癌 癌症 生物 基因 医学 前列腺 癌症研究 雄激素受体 内科学 生物信息学 内分泌学 遗传学
作者
Guojiang Wei,Hongcai Zhu,Yupeng Zhou,Yang Pan,Bocun Yi,Yang-Kai Bai
出处
期刊:Translational Oncology [Elsevier]
卷期号:44: 101925-101925
标识
DOI:10.1016/j.tranon.2024.101925
摘要

Prostate cancer is the most frequently diagnosed cancer among men in the United States and is the second leading cause of cancer-related deaths in men. The incidence of prostate cancer is gradually rising due to factors such as aging demographics and changes in dietary habits. The objective of this study is to investigate the metabolic reprogramming changes occurring in prostate cancer and identify potential therapeutic targets. In this study, we utilized single-cell sequencing to comprehensively characterize the alterations in metabolism and the regulatory role of transcription factors in various subtypes of prostate cancer. In comparison to benign prostate tissue, prostate cancer displayed substantial metabolic variations, notably exhibiting heightened activity in fatty acid metabolism and cholesterol metabolism. This metabolic reprogramming not only influenced cellular energy utilization but also potentially impacted the activity of the androgen receptor (AR) pathway through the synthesis of endogenous steroid hormones. Through our analysis of transcription factor activity, we identified the crucial role of SREBPs, which are transcription factors associated with lipid metabolism, in prostate cancer. Encouragingly, the inhibitor Betulin effectively suppresses prostate cancer growth, highlighting its potential as a therapeutic agent for prostate cancer treatment.
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