相互作用体
生物
计算生物学
酶
细菌
细胞信号
信号转导
细胞生物学
生物化学
遗传学
基因
作者
Lu Liu,Janine L. Gray,Edward W. Tate,Aimin Yang
标识
DOI:10.1016/j.tibtech.2023.05.004
摘要
Bacteria have evolved a diverse set of enzymes that enable them to subvert host defense mechanisms as well as to form part of the prokaryotic immune system. Due to their unique and varied biochemical activities, these bacterial enzymes have emerged as key tools for understanding and investigating biological systems. In this review, we summarize and discuss some of the most prominent bacterial enzymes used for the site-specific modification of proteins, in vivo protein labeling, proximity labeling, interactome mapping, signaling pathway manipulation, and therapeutic discovery. Finally, we provide a perspective on the complementary advantages and limitations of using bacterial enzymes compared with chemical probes for exploring biological systems.
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