蛋白酵素
组织因子
凝血酶
凝结
血管生成
丝氨酸蛋白酶
蛋白酶
癌症研究
癌症
蛋白酶激活受体
癌细胞
凝血活酶
受体
生物
细胞生物学
生物化学
免疫学
酶
血小板
医学
内科学
遗传学
作者
M. T. Sampson,Ajay K. Kakkar
出处
期刊:Biochemical Society Transactions
[Portland Press]
日期:2002-04-01
卷期号:30 (2): 201-207
被引量:75
摘要
Tumours are capable of activating blood coagulation through the expression of procoagulant molecules such as tissue factor, cancer procoagulant and hepsin. Initiation of the clotting cascade results in the generation of the activated serine proteases factor VIIa, factor Xa and thrombin. These proteases act via protease-activated receptors and tissue factor to alter gene expression, thereby modulating tumour cell growth, invasion, metastasis and angiogenesis.
科研通智能强力驱动
Strongly Powered by AbleSci AI