活性氧
纳米颗粒
纳米技术
氧化应激
突变
DNA损伤
纳米毒理学
脂质过氧化
纳米医学
生物物理学
毒性
化学
生物分子
材料科学
生物化学
DNA
生物
突变
有机化学
基因
作者
Zhongjie Yu,Qi Li,Jing Wang,Yali Yu,Yin Wang,Qihui Zhou,Peifeng Li
标识
DOI:10.1186/s11671-020-03344-7
摘要
Abstract The unique physicochemical characteristics of nanoparticles have recently gained increasing attention in a diverse set of applications, particularly in the biomedical field. However, concerns about the potential toxicological effects of nanoparticles remain, as they have a higher tendency to generate excessive amounts of reactive oxygen species (ROS). Due to the strong oxidation potential, the excess ROS induced by nanoparticles can result in the damage of biomolecules and organelle structures and lead to protein oxidative carbonylation, lipid peroxidation, DNA/RNA breakage, and membrane structure destruction, which further cause necrosis, apoptosis, or even mutagenesis. This review aims to give a summary of the mechanisms and responsible for ROS generation by nanoparticles at the cellular level and provide insights into the mechanics of ROS-mediated biotoxicity. We summarize the literature on nanoparticle toxicity and suggest strategies to optimize nanoparticles for biomedical applications.
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