过氧化物酶体增殖物激活受体
过氧化物酶体
核受体
受体
脂肪组织
脂质代谢
生物化学
生物
PPAR激动剂
化学
转录因子
基因
作者
Rachel Marion‐Letellier,Guillaume Savoye,Subrata Ghosh
标识
DOI:10.1016/j.ejphar.2015.11.004
摘要
Peroxisome proliferator-activated receptor γ (PPARγ) belongs to the family of nuclear nuclear receptors and is mainly expressed in adipose tissue, hematopoietic cells and the large intestine. Contrary to other nuclear receptors that mainly bind a single specific ligand, there are numerous natural PPARγ ligands, in particular fatty acids or their derivatives called eicosanoids. PPARγ have pleiotropic functions: (i) glucose and lipid metabolism regulation, (ii) anti-inflammatory properties, (iii) oxidative stress inhibition, (iv) improvement of endothelial function. Its role has been mainly studied by the use synthetic agonists. In this review, we will focus on the effects of PPARγ mediated through fatty acids and how these have beneficial health properties.
科研通智能强力驱动
Strongly Powered by AbleSci AI