纳米载体
药物输送
白蛋白
生物相容性
牛血清白蛋白
纳米囊
药品
免疫原性
纳米技术
靶向给药
纳米医学
药理学
化学
医学
材料科学
纳米颗粒
免疫学
生物化学
免疫系统
有机化学
作者
Mahdi Karimi,Sajad Bahrami,Soodeh Baghaee Ravari,Parham Sahandi Zangabad,Hamed Mirshekari,Mahnaz Bozorgomid,Somayeh Shahreza,Masume Sori,Michael R. Hamblin
标识
DOI:10.1080/17425247.2016.1193149
摘要
Introduction: One of the biggest impacts that the nanotechnology has made on medicine and biology, has been in the area of drug delivery systems (DDSs). Many drugs suffer from serious problems concerning insolubility, instability in biological environments, poor uptake into cells and tissues, sub-optimal selectivity for targets and unwanted side effects. Nanocarriers can be designed as DDSs to overcome many of these drawbacks. One of the most versatile building blocks to prepare these nanocarriers is the ubiquitous, readily available and inexpensive protein, serum albumin.Areas covered: This review covers the use of different types of albumin (human, bovine, rat, and chicken egg) to prepare nanoparticle and microparticle-based structures to bind drugs. Various methods have been used to modify the albumin structure. A range of targeting ligands can be attached to the albumin that can be recognized by specific cell receptors that are expressed on target cells or tissues.Expert opinion: The particular advantages of albumin used in DDSs include ready availability, ease of chemical modification, good biocompatibility, and low immunogenicity. The regulatory approvals that have been received for several albumin-based therapeutic agents suggest that this approach will continue to be successfully explored.
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