Analysis of GIPC1 CGG repeat expansions in essential tremor

Despite the high prevalence of familial aggregation in Essential tremor (ET) patients, the understanding of the pathogenesis of ET is still limited, and the findings of genes/loci were not consistently replicated. Previous studies found CGG repeat expansions of NOTCH2NLC were related to ET, providing a possible direction to explore pathogenic/risk genes of ET [1]. We recently read the paper published by Xi et al. and Deng et al. which showed that 5′ UTR CGG repeat expansions in GIPC1 were associated with OPDM [2,3].