| 标题 |
 The increase of Nrf2 m6A modification induced by FTO downregulation promotes hippocampal neuron injury and aggravates the progression of epilepsy in a rat model FTO下调诱导的Nrf2 m6A修饰增加促进大鼠海马神经元损伤并加速癫痫的进展
相关领域
海马结构
下调和上调
癫痫
神经元
化学
大鼠模型
内科学
生物
医学
神经科学
生物化学
基因
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| 网址 | |
| DOI | |
| 其它 | Epilepsy is a common chronic neurological disorder characterized by widespread neuronal death. The purpose of this study was to investigate the role of nuclear factor erythroid 2-related factor 2 (Nrf2) m6A methylation in epilepsy. To create epileptic models, the rats were given Lithium chloride and pilocarpine, and isolated primary rat hippocampal neurons were cultured in an Mg2+ -free medium. The frequency of seizures was recorded in the epilepsy group of rats. The functional tests included TUNEL, MTT, and flow cytometry. Mechanistically, RNA degradation assay, RNA immunoprecipitation, and methylated RNA immunoprecipitation were performed. In epileptic models, Nrf2 and fat mass and obesity-associated (FTO) levels were downregulated, whereas YT521-B homology (YTH) domain family protein 2 (YTHDF2) was upregulated. |
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爱静静
VDC
劲秉
Xiaoxiao
热心路人
ccc
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YifanWang
迟大猫
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kingwill
苗条绝义
Emon
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Agernon
缓慢如南
小林太郎
mmyhn
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