PROPIONIBACTERIUM ACNES ASSOCIATED WITH INFLAMMATION IN RADICAL PROSTATECTOMY SPECIMENS: A POSSIBLE LINK TO CANCER EVOLUTION?

No AccessJournal of UrologyAdult Urology: Infection/Inflammation1 Jun 2005PROPIONIBACTERIUM ACNES ASSOCIATED WITH INFLAMMATION IN RADICAL PROSTATECTOMY SPECIMENS: A POSSIBLE LINK TO CANCER EVOLUTION? RONALD J. COHEN, BEVERLEY A. SHANNON, JOHN E. McNEAL, TOM SHANNON, and KERRYN L. GARRETT RONALD J. COHENRONALD J. COHEN , BEVERLEY A. SHANNONBEVERLEY A. SHANNON , JOHN E. McNEALJOHN E. McNEAL , TOM SHANNONTOM SHANNON , and KERRYN L. GARRETTKERRYN L. GARRETT View All Author Informationhttps://doi.org/10.1097/01.ju.0000158161.15277.78AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Inflammation is commonly observed in the prostate gland and has been implicated in the development of prostate cancer. The etiology of prostatic inflammation is unknown. However, the involvement of a carcinogenic infectious agent has been suggested. Materials and Methods: Prostatic tissue from 34 consecutive patients with prostate cancer was cultured to detect the presence of bacterial agents. Prostatic inflammation was assessed by histological examination of wholemount tissue sections. Results: The predominant microorganism detected was Propionibacterium acnes, found in 35% of prostate samples. A significantly higher degree of prostatic inflammation was observed in cases culture positive for P. acnes (p =0.007). P. acnes was separated into 3 groups based on cell surface properties, phenotype and genetic grouping. All skin control isolates were classified as group 1 whereas most prostatic isolates were classified as groups 2 and 3. Conclusions: P. acnes has been isolated from prostatic tissues in men who underwent radical prostatectomy for localized cancer and has been shown to be positively associated with prostatic inflammation. This inflammation may then be linked to the evolution of carcinoma. 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Google Scholar From Uropath Pty Ltd (RJC), Tissugen Pty Ltd (BAS, KLG) and Hollywood Specialist Centre (TS), Perth, Western Australia, and the Department of Urology, Stanford University, Stanford, California (JEM)© 2005 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited ByShrestha E, White J, Yu S, Kulac I, Ertunc O, De Marzo A, Yegnasubramanian S, Mangold L, Partin A and Sfanos K (2018) Profiling the Urinary Microbiome in Men with Positive versus Negative Biopsies for Prostate CancerJournal of Urology, VOL. 199, NO. 1, (161-171), Online publication date: 1-Jan-2018.Fujita K, Hosomi M, Tanigawa G, Okumi M, Fushimi H and Yamaguchi S (2018) Prostatic Inflammation Detected in Initial Biopsy Specimens and Urinary Pyuria are Predictors of Negative Repeat Prostate BiopsyJournal of Urology, VOL. 185, NO. 5, (1722-1727), Online publication date: 1-May-2011.Galobardes B, Smith G, Jeffreys M, Kinra S and McCarron P (2018) Acne in Adolescence and Cause-Specific Mortality: Lower Coronary Heart Disease but Higher Prostate Cancer Mortality. The Glasgow Alumni Cohort StudyJournal of Urology, VOL. 175, NO. 1, (152-152), Online publication date: 1-Jan-2006. Volume 173Issue 6June 2005Page: 1969-1974 Advertisement Copyright & Permissions© 2005 by American Urological Association, Inc.Keywordsprostatic neoplasmspropionibacterium acnesinflammationMetricsAuthor Information RONALD J. COHEN Financial interest and/or other relationship with Tissugen Pty Ltd. More articles by this author BEVERLEY A. SHANNON Nothing to disclose. More articles by this author JOHN E. McNEAL Nothing to disclose. More articles by this author TOM SHANNON Nothing to disclose. More articles by this author KERRYN L. GARRETT Nothing to disclose. More articles by this author Expand All Advertisement PDF DownloadLoading ...