CYP2E1
对乙酰氨基酚
化学
体内
药理学
肝损伤
乙醇
肝细胞
细胞凋亡
生物化学
新陈代谢
细胞色素P450
体外
医学
生物
生物技术
作者
Sijing Dong,Jianbo Ji,Baofang Zhang,Lingyun Hu,Xiangzhen Cui,Haina Wang
出处
期刊:PubMed
日期:2018-11-01
卷期号:73 (11): 666-670
被引量:10
摘要
Hovenia dulcis Thunb. is a traditional hepatoprotective Chinese medicine, and in research, much effort has been focused on the protection against alcoholic liver injury. In this study, the protective effects of a fruit ethanol extract of Hovenia dulcis (FE) against APAP-induced acute hepatotoxicity in mice and the possibly involved molecular mechanisms were investigated. Hepatoprotective activity of FE is clearly indicated by histopathological and biochemical examination. Treatment with FE resulted in inhibition of CYP2E1 activity involved in the transformation of APAP in vivo. Expressions of the altered bile acid metabolism and transport-related genes and relative proteins of apoptosis were normalized by preconditioning with FE before APAP treatment. These results suggested FE to alleviate APAP-induced liver injury in a dose-dependent manner by inhibition of cytochrome P450 activity, hepatocyte apoptosis and regulation of bile acid homeostasis imbalance.
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