One-year outcomes after stereotactic body radiotherapy for refractory ventricular tachycardia

医学 耐火材料(行星科学) 室性心动过速 胺碘酮 烧蚀 心动过速 放射治疗 放射外科 心脏病学 前瞻性队列研究 内科学 心房颤动 天体生物学 物理
作者
Jeffrey Arkles,Tim M. Markman,Rachel Trevillian,Nikhil Yegya‐Raman,Lohit Garg,Saman Nazarian,Pasquale Santangeli,Fermin C. García,David J. Callans,David S. Frankel,Gregory E. Supple,David Lin,Malcolm Riley,Ramanan Kumaraeswaran,Francis E. Marchlinski,Robert D. Schaller,Benoit Desjardins,Hongyu Chen,Ontida Apinorasethkul,Michelle Alonso‐Basanta,Eric S. Diffenderfer,Michele M. Kim,Steven J. Feigenberg,Wei Zou,Jacklyn Marcel,Keith A. Cengel
出处
期刊:Heart Rhythm [Elsevier BV]
卷期号:21 (1): 18-24 被引量:12
标识
DOI:10.1016/j.hrthm.2023.10.005
摘要

Abstract:

Background

Cardiac stereotactic body radiotherapy (SBRT) has emerged as a promising noninvasive treatment for refractory ventricular tachycardia (VT).

Objective

Describe the safety and effectiveness of SBRT for VT in refractory to extensive ablation.

Methods

After maximal medical and ablation therapy patients were enrolled in a prospective registry. Available electrophysiologic and imaging data were integrated to generate a plan target volume (PTV) All SBRT was planned with a single 25 gray fraction utilizing respiratory motion mitigation strategies. Clinical outcomes at 6 weeks, 6 months and 12 months were analyzed and compared to the 6 months prior to treatment. The VT burden (ICD shocks and ATP sequences) as well as clinical and safety outcomes were the main outcomes.

Results

15 patients were enrolled and planned. 14 underwent treatment with 12 surviving to the end of the 6-week period and 10 surviving to 12 months. From 6 week to 12 months there was recurrence of VT which resulted in either appropriate ATP or ICD shocks in 33% (4/12). There were significant reductions in treated VT at 6 weeks to 6 months (98%) and 12 (99%) months compared to the 6 months prior to treatment. There was a nonsignificant trend towards lower amiodarone dose at 12 months. 4 deaths occurred after treatment with no changes in ventricular function.

Conclusion

For a select group of high-risk patients with VT refractory to standard therapy, SBRT is associated with a reduction of in VT and appropriate ICD therapies over 1 year.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
feifei发布了新的文献求助30
刚刚
丘比特应助悠悠爱学习采纳,获得10
1秒前
Janet发布了新的文献求助10
1秒前
研友_Z33zkZ发布了新的文献求助10
1秒前
CR7应助小宋宋采纳,获得20
1秒前
852应助望北楼主采纳,获得10
1秒前
七月流火给阅知的求助进行了留言
1秒前
kiss完成签到,获得积分10
2秒前
白色风车发布了新的文献求助10
2秒前
2秒前
毛毛虫发布了新的文献求助10
3秒前
菲菲完成签到,获得积分10
3秒前
LYSM应助宁阿霜采纳,获得10
4秒前
愤怒的茉莉完成签到,获得积分10
4秒前
纯真醉波完成签到 ,获得积分10
4秒前
4秒前
leez完成签到,获得积分20
5秒前
踏实的星星完成签到,获得积分20
5秒前
CipherSage应助CJ采纳,获得10
5秒前
5秒前
欣慰的笑阳完成签到 ,获得积分10
5秒前
小二郎应助Spark采纳,获得10
5秒前
6秒前
6秒前
zz发布了新的文献求助10
7秒前
科目三应助饱满的小甜瓜采纳,获得10
7秒前
Akim应助科研通管家采纳,获得10
7秒前
SYLH应助科研通管家采纳,获得10
7秒前
科研通AI2S应助科研通管家采纳,获得10
7秒前
SYLH应助科研通管家采纳,获得10
8秒前
8秒前
8秒前
8秒前
8秒前
8秒前
8秒前
Akim应助科研通管家采纳,获得10
8秒前
LUCA发布了新的文献求助10
8秒前
8秒前
WeiBao发布了新的文献求助10
8秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974844
求助须知:如何正确求助?哪些是违规求助? 3519270
关于积分的说明 11197844
捐赠科研通 3255496
什么是DOI,文献DOI怎么找? 1797791
邀请新用户注册赠送积分活动 877187
科研通“疑难数据库(出版商)”最低求助积分说明 806202