诊断生物标志物
细胞外小泡
医学
生物标志物
胆道
癌症
内科学
生物信息学
病理
生物
生物化学
细胞生物学
作者
Fang Bao,Jiayue Liu,Jing Wang,Miao Lü,Zhaochao Xu,Guixin Zhang
出处
期刊:Cancers
[MDPI AG]
日期:2022-08-13
卷期号:14 (16): 3921-3921
被引量:7
标识
DOI:10.3390/cancers14163921
摘要
Cholangiocarcinoma (CCA) is a multifactorial malignant tumor of the biliary tract, and the incidence of CCA is increasing in recent years. At present, the diagnosis of CCA mainly depends on imaging and invasive examination, with limited specificity and sensitivity and late detection. The early diagnosis of CCA always faces the dilemma of lacking specific diagnostic biomarkers. Non-invasive methods to assess the degree of CAA have been developed throughout the last decades. Among the many specimens looking for CCA biomarkers, bile has gotten a lot of attention lately. This paper mainly summarizes the recent developments in the current research on the diagnostic biomarkers for CCA in human bile at the levels of the gene, protein, metabolite, extracellular vesicles and volatile organic compounds.
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