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Interaction behavior of curcumin encapsulated onto functionalized SBA-15 as an efficient carrier and release in drug delivery

姜黄素 化学 介孔二氧化硅 介孔材料 动力学 核化学 吸附 药物输送 磷酸盐缓冲盐水 化学工程 色谱法 有机化学 催化作用 生物化学 工程类 量子力学 物理
作者
Nidhal A. Atiyah,Talib M. Albayati,Mohammed A. Atiya
出处
期刊:Journal of Molecular Structure [Elsevier BV]
卷期号:1260: 132879-132879 被引量:83
标识
DOI:10.1016/j.molstruc.2022.132879
摘要

• SBA-15 and NH2/SBA-15 mesoporous were synthesized and modified with amino groups. • Curcumin was loaded onto mesoporous surfaces and pores by Adsorption method. • Method of loading with amino groups was influenced with curcumin release. • The results revealed curcumin bonding to the SBA-15 and NH 2 /SBA-15 Nano carriers. • NH 2 /SBA-15was found very active for loading and release of curcumin. In this work, mesoporous silica SBA-15 was prepared and functionalized with amine groups (i.e., NH 2 ) to form NH 2 /SBA-15. The curcumin (CUR) was encapsulated into the surface and pore of NH 2 /SBA-15 to create CUR@NH 2 /SBA-15 as an efficient carrier in drug delivery systems (DDSs). The three samples (i.e., SBA-15, NH 2 /SBA-15, and CUR@NH 2 /SBA-15) were characterized. The study investigated the effect of the carrier dose, initial CUR concentration, pH, and contact time on the CUR loading efficiency (DLE%) via adsorption. The best DLE% for the SBA-15 and NH 2 /SBA-15 were found to be 45% and 89.7%, respectively. The Langmuir isotherm had a greater correlation coefficient (R 2 ) of 0.998 for SBA-15. A pseudo-second-order kinetic model seemed to fit well with R 2 = 0.9998 for SBA-15 and R 2 = 0.9993 for NH 2 /SBA-15. A phosphate buffer solution (PBS) with a pH of 7.4 was utilized to study the CUR release behavior. As a result, the full release after 72 h was found to have a maximum of 82.6% and 41.2% for SBA-15 and NH 2 /SBA-15, respectively. The first-order, Weibull, Hixson-Crowell, Korsmeyer-Peppas, and Higuchi kinetic release models were applied. The Weibull model estimated the kinetics of the CUR release from SBA-15 and NH 2 /SBA-15 with R 2 = 0.814 and 0.808, respectively. .
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