视神经脊髓炎
神经科学
水通道蛋白4
肌萎缩侧索硬化
多发性硬化
中枢神经系统
疾病
突触可塑性
平衡
神经退行性变
水通道蛋白
冲程(发动机)
神经系统
生物
癫痫
医学
病理
免疫学
内科学
生理学
受体
工程类
机械工程
作者
Jacqueline A. Hubbard,Jenny I. Szu,Devin K. Binder
标识
DOI:10.1016/j.brainresbull.2017.02.011
摘要
Since the discovery of aquaporins, it has become clear that the various mammalian aquaporins play critical physiological roles in water and ion balance in multiple tissues. Aquaporin-4 (AQP4), the principal aquaporin expressed in the central nervous system (CNS, brain and spinal cord), has been shown to mediate CNS water homeostasis. In this review, we summarize new and exciting studies indicating that AQP4 also plays critical and unanticipated roles in synaptic plasticity and memory formation. Next, we consider the role of AQP4 in Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), multiple sclerosis (MS), neuromyelitis optica (NMO), epilepsy, traumatic brain injury (TBI), and stroke. Each of these conditions involves changes in AQP4 expression and/or distribution that may be functionally relevant to disease physiology. Insofar as AQP4 is exclusively expressed on astrocytes, these data provide new evidence of "astrocytopathy" in the etiology of diverse neurological diseases.
科研通智能强力驱动
Strongly Powered by AbleSci AI