微生物学
肺炎链球菌
溶解循环
噬菌体
血清型
肺炎球菌感染
生物
溶血素
青霉素
效价
酶
病毒学
抗生素
病毒
大肠杆菌
基因
生物化学
作者
Jutta M. Loeffler,Daniel Nelson,Vincent A. Fischetti
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2001-12-07
卷期号:294 (5549): 2170-2172
被引量:484
标识
DOI:10.1126/science.1066869
摘要
Nasopharyngeal carriage is the major reservoir for Streptococcus pneumoniae in the community. Although eliminating this reservoir would greatly reduce disease occurrence, no suitable intervention has been available for this purpose. We show here that seconds after contact, a purified pneumococcal bacteriophage lytic enzyme (Pal) is able to kill 15 common serotypes of pneumococci, including highly penicillin-resistant strains. In vivo, previously colonized mice revealed undetectable pneumococcal titers 5 hours after a single enzyme treatment. Pal enzyme had little or no effect on microorganisms normally found in the human oropharynx, and Pal-resistant pneumococci could not be detected after extensive exposure to the enzyme.
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