细胞外
代谢工程
胞外聚合物
代谢途径
胞外多糖
生物合成
生物化学
化学
细菌
生物
生物膜
新陈代谢
酶
多糖
遗传学
作者
Xiaoyu Wei,Zhen Chen,Ailing Liu,Lijie Yang,Yiyuan Xu,Mingfeng Cao,Ning He
标识
DOI:10.1016/j.biotechadv.2023.108199
摘要
Extracellular polymeric substances are mainly synthesized via a variety of biosynthetic pathways in bacteria. Bacilli-sourced extracellular polymeric substances, such as exopolysaccharides (EPS) and poly-γ-glutamic acid (γ-PGA), can serve as active ingredients and hydrogels, and have other important industrial applications. However, the functional diversity and widespread applications of these extracellular polymeric substances, are hampered by their low yields and high costs. Biosynthesis of extracellular polymeric substances is very complex in Bacillus, and there is no detailed elucidation of the reactions and regulations among various metabolic pathways. Therefore, a better understanding of the metabolic mechanisms is required to broaden the functions and increase the yield of extracellular polymeric substances. This review systematically summarizes the biosynthesis and metabolic mechanisms of extracellular polymeric substances in Bacillus, providing an in-depth understanding of the relationships between EPS and γ-PGA synthesis. This review provides a better clarification of Bacillus metabolic mechanisms during extracellular polymeric substance secretion and thus benefits their application and commercialization.
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