Hemocompatible nucleosome-inspired heparin-mimicking hydrogel microspheres for safe and efficient extracorporeal removal of circulating histones in critically ill patients

The tailored RCHMs can adsorb circulating histones through electrostatic interactions with excellent hemocompatibility and significantly attenuate histone-mediated thrombocytopenia, platelet aggregation, and endothelial cell death.