免疫系统
炎症
材料科学
钙
单核细胞
药物输送
骨愈合
骨髓
辛伐他汀
免疫学
医学
巨噬细胞
生物医学工程
药理学
内科学
生物
外科
纳米技术
生物化学
体外
作者
Jumana Alhamdi,Tao Peng,Iman M. Al-Naggar,Kelly L. Hawley,Kara L. Spiller,Liisa T. Kuhn
出处
期刊:Biomaterials
[Elsevier]
日期:2019-03-01
卷期号:196: 90-99
被引量:83
标识
DOI:10.1016/j.biomaterials.2018.07.012
摘要
Older adults suffer from weakened and delayed bone healing due to age-related alterations in bone cells and in the immune system. Given the interaction between the immune system and skeletal cells, therapies that address deficiencies in both the skeletal and the immune system are required to effectively treat bone injuries of older patients. The sequence of macrophage activation observed in healthy tissue repair involves a transition from a pro-inflammatory state followed by a pro-reparative state. In older patients, inflammation is slower to resolve and impedes healing. The goal of this study was to design a novel drug delivery system for temporal guidance of the polarization of macrophages using bone grafting materials. A biomimetic calcium phosphate coating (bCaP) physically and temporally separated the pro-inflammatory stimulus interferon-gamma (IFNγ) from the pro-reparative stimulus simvastatin (SIMV). Effective doses were identified using a human monocyte line (THP-1) and testing culminated with bone marrow macrophages obtained from old mice. Sequential M1-to-M2 activation was achieved with both cell types. These results suggest that this novel immunomodulatory drug delivery system holds potential for controlling macrophage activation in bones of older patients.
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