蛋白质降解
蛋白酶体
泛素
药物发现
蛋白质质量
溶酶体
计算生物学
计算机科学
生物
细胞生物学
生物信息学
生物化学
酶
基因
作者
Ting He,Chenxi Wen,Guodong Yang,Xuekang Yang
标识
DOI:10.1002/adbi.202300083
摘要
Abstract Protein degradation is a general process to maintain cell homeostasis. The intracellular protein quality control system mainly includes the ubiquitin‐proteasome system and the lysosome pathway. Inspired by the physiological process, strategies to degrade specific proteins have developed, which emerge as potent and effective tools in biological research and drug discovery. This review focuses on recent advances in targeted protein degradation techniques, summarizing the principles, advantages, and challenges. Moreover, the potential applications and future direction in biological science and clinics are also discussed.
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