“AHR-ming” host defense against cryptosporidiosis

Globally, cryptosporidiosis is a leading cause of childhood diarrheal disease and is a major risk factor for malnutrition and impairment of growth and cognitive development. In this issue of Cell Host & Microbe, Maradana et al. identify a target for dietary enhancement of innate immune defenses against cryptosporidiosis. Globally, cryptosporidiosis is a leading cause of childhood diarrheal disease and is a major risk factor for malnutrition and impairment of growth and cognitive development. In this issue of Cell Host & Microbe, Maradana et al. identify a target for dietary enhancement of innate immune defenses against cryptosporidiosis. Dietary environmental factors shape the immune defense against Cryptosporidium infectionMaradana et al.Cell Host & MicrobeDecember 4, 2023In BriefCryptosporidium causes global diarrheal disease. Maradana, Marzook, et al. discover that certain intestinal immune cells, whose survival and function rely on AHR expression, play a vital role in defending against Cryptosporidium infection. Diet supplementation with AHR ligands enhances the anti-cryptosporidial activity of these immune cells. Full-Text PDF Open Access