溃疡性结肠炎
微泡
肠道菌群
免疫学
微生物群
微生物学
生物
医学
内科学
生物化学
生物信息学
基因
小RNA
疾病
作者
Feng Gao,Shenghui Wu,Kang Zhang,Zhiming Xu,Xin Zhang,Zhengjin Zhu,Fusheng Quan
标识
DOI:10.1021/acs.jafc.4c03212
摘要
Goat milk is rich in a variety of nutrients that are important for intestinal health and disease prevention. However, the role of exosomes in goat milk remains to be elucidated. This study investigated for the first time the therapeutic efficacy and molecular underlying mechanisms of mature milk exosomes (M-exo) and goat colostrum exosomes (C-exo) on dextran sodium sulfate-induced ulcerative colitis (UC) in mice. The findings demonstrate that M-exo and C-exo significantly improved physiological indices, suppressed the secretion of proinflammatory cytokines, and diminished oxidative stress and apoptosis in UC mice. Moreover, C-exo and M-exo restored the intestinal barrier function, remodeled the gut microbiota, and improved metabolite composition in the feces of colitis mice. In conclusion, goat milk exosomes ameliorate UC in mice, which provides a basis for the development of functional food applications for the prevention and treatment of inflammatory bowel disease.
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