Multi‐Chambered Core/Shell Supraparticles for Real‐Time, Full‐Time Diagnosis and Treatment Integration of Tumors

Abstract To a certain extent, theranostic nanoplatforms promote tumor treatment efficiency. However, timely monitoring of the critical stages and signal sustainability of the entire process is challenging. In this study, multi‐chambered core/shell magnetic nanoparticles (MC‐MNPs) as drug and imaging agent multi‐loaded nanocarriers with a synergistic release function are reported. Supraparticles with stable chambers are formed by the supercooling self‐assembly of several core/shell magnetic nanoparticles composed of amphiphilic copolymers as the core and hydrophilic magnetic iron oxide nanoparticles as the shell. Desalinized doxorubicin and coumarin 6 are stored in different cavities of nanocarriers, and chitosan is used as an outer encapsulation layer. Based on their construction properties, MC‐MNPs can exhibit gradient‐degraded and steady‐released controllability in the tumor environment. Furthermore, real‐time accumulation situations and full‐time diagnostic signals of nanocarriers are thoroughly demonstrated using fluorescence imaging and T 2 ‐weighted magnetic resonance imaging before and after magnetic hyperthermia in targeted tumors under an alternating magnetic field. Thus, MC‐MNPs as theranostic nanocarriers exhibit great potential for the timely monitoring and full‐time guidance of tumor treatment.