载脂蛋白B
第一代
肽
计算生物学
第三代
化学
生物化学
生物
医学
计算机科学
胆固醇
人口
电信
环境卫生
作者
Abhay H. Pande,Sunil A. Nankar,Sakeel Ahmed,Shyam Sunder Sharma
出处
期刊:Current Protein & Peptide Science
[Bentham Science]
日期:2022-11-01
卷期号:23 (11): 757-772
被引量:1
标识
DOI:10.2174/1389203723666221003122624
摘要
Apolipoprotein-mimetic peptides, mimicking the biological properties of apolipoproteins, have shown beneficial properties against various diseases (central and peripheral diseases) and have emerged as potential candidates for their treatments. Progress has been made from first-generation to second-generation apolipoprotein-mimetic peptides. Understanding these peptides from the first generation to the second generation is discussed in this review. First, we discussed the structural and therapeutic potentials of first-generation apolipoprotein-mimetic peptides. Further, we discussed the development of second-generation apolipoprotein-mimetic peptides, like dual-domain and bihelical peptides the emergence of second-generation apolipoprotein-mimetic peptides as potential candidates in different preclinical and clinical studies has also been emphasized.
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