Myopia animal model plays an important role in mechanism study on myopia. Recently, mice are increasingly used in myopia animal model. Using mouse as myopic animal model has several advantages, especially in the mechanism study. However, the mice eye is much smaller in size than other animal eyes, therefore it is very difficult to measure the refraction and ocular dimensions in vivo. Here are summaries and comments round disputed issues which are expected to be useful for animal myopia researches.