归巢(生物学)
干细胞
细胞外基质
造血
细胞生物学
祖细胞
生物
医学
发病机制
癌症研究
病理
免疫学
骨髓
生态学
作者
Masataka Sata,Akio Saiura,Atsushi Kunisato,Akihiro Tojo,Seiji Okada,Takeshi Tokuhisa,Hisamaru Hirai,Masatoshi Makuuchi,Yasunobu Hirata,Ryozo Nagai
出处
期刊:Nature Medicine
[Springer Nature]
日期:2002-04-01
卷期号:8 (4): 403-409
被引量:1167
摘要
Excessive accumulation of smooth-muscle cells (SMCs) has a key role in the pathogenesis of vascular diseases. It has been assumed that SMCs derived from the outer medial layer migrate, proliferate and synthesize extracellular matrix components on the luminal side of the vessel. Although much effort has been devoted to targeting migration and proliferation of medial SMCs, there is no effective therapy that prevents occlusive vascular remodeling. We show here that in models of post-angioplasty restenosis, graft vasculopathy and hyperlipidemia-induced atherosclerosis, bone-marrow cells give rise to most of the SMCs that contribute to arterial remodeling. Notably, purified hematopoietic stem cells differentiate into SMCs in vitro and in vivo. Our findings indicate that somatic stem cells contribute to pathological remodeling of remote organs, and may provide the basis for the development of new therapeutic strategies for vascular diseases through targeting mobilization, homing, differentiation and proliferation of bone marrow-derived vascular progenitor cells.
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